17.12.2015: Elena Agliari

 

From the previous talk it will appear that several networks in the immune system do work in under-percolated regimes. As a consequence attention should be paied on small cliques of interacting B and T clones alone.

In this talk I will show that the biochemistry underlying these dialogues has the same mathematical structure of dynamical systems in (biological) neural networks as well as that of transfer-functions in the electronic counterpart. 

In particular I will show how to relate cooperative/ultrasensitive kinetics (biochemistry) with ferromagnets (statistical mechanics) and operational amplifiers (electronics); anticooperative kinetics (biochemistry) with antiferromagnets (statistical mechanics) and flip-flops (electronics). 

Bio-Logic stochastic gates will be constructed via statistical mechanics, proved to work properly via logic and tested on real data regarding the related biochemistry.

 

Reference papers:

E. Agliari et al., Collective behaviour: from biochemical kinetics to gelectronic circuits, Nature Sci. Rep. 3, 3458 (2013).

E. Agliari et al., Cancer driven dynamics of immune cells in a microfluidic environment, Nature Sci. Rep. 4, 6639 (2014).

E. Agliari et al., Notes on stochastic (bio)-logic gates, Nature Sci. Rep. 5, 9415 (2015).