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SLM FAQ (Frequently Asked Questions)
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SLM FAQ

(Frequently Asked Questions)



What is SLM?

SLM is an open-source software to analyze data obtained by Chromatin ImmunoPrecipitation (ChIP) on tiling arrays (chip).



SLM Versions

The first SLM release, version 1.02, occurred on Jan 2007.
It contains the core features of the software as described below.


Main Features of SLM

  • Background correction
  • Normalization
  • Enrichment
  • Peaks detection
Please, refer to the online documentation



Installing SLM?

Sources and documentation for released versions of SLM packages can be downloaded from the SLM website.

For Unix/Linux
Installing SLM

   1. Download the most recent version of the source code of SLM from the website
   2. Unzip the package

          %> unzip SLMplus_v?.zip

   3. compile with the provided makefile by typing on the terminal

          %> make SLM


For MAC OS
Installing SLM

   1. Download the most recent version of the source code of SLM from the website
   2. Unzip the package preserving the directory structure, e.g. in the folder /usr/local/bin/SLM/
   3. Run a terminal
   4. Access the directory where the SLM package has been unzipped. E.g.

         %> cd /usr/local/bin/SLM

   5. Compile with the provided makefile

         %> make SLM

        If DarwinPorts has been used to port the GSL library, specify the library path with the LIBPATH option

         %> make SLM LIBPATH=/opt/local

        If Fink has been used to port the GSL library, specify the library path with the LIBPATH option

         %> make SLM LIBPATH=/sw


For Windows
SLM has not yet been tested on Windows systems.


Other Notes
SLM requires GSL libraries to compile successfully.
Without proper installation of the required libraries, SLM will fail to install on your system.



What documentation exists for SLM?

Documentation for SLM is available on the WWW.

  • Online help: Online documentation for most of the functions and methods in SLM exists, and can be visualized from this website
  • Publications: The reference article describing the main methods and algorithms for SLM is “Identifying synergistic regulation involving c-Myc and sp1 in human tissues.” (Parisi, Wirapati and Naef – NAR 2007). A link is available in the "Publications" section of this website.


Citing SLM

At this point, to cite SLM in publications, please use the following article,
  • “Identifying synergistic regulation involving c-Myc and sp1 in human tissues.” (Parisi, Wirapati and Naef – NAR 2007).



SLM Bugs

What is a bug?:
Taking forever to complete a command can be a bug, but you must make certain that it was really SLM's fault. Some commands simply take a long time. If the input was such that you know it should have been processed quickly, report a bug. If you don't know whether the command should take a long time, find out by looking in the manual or by asking for assistance.

It is very useful to try and find simple examples that produce apparently the same bug, and somewhat useful to find simple examples that might be expected to produce the bug but actually do not. If you want to debug the problem and find exactly what caused it, that is wonderful. You should still report the facts as well as any explanations or solutions. Please include an example that reproduces the problem, preferably the simplest one you have found.

last updated - 2006-11-20

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